School of MedTech
Medicine // Engineering
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Syllabus
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Purpose
Syllabus
Life and the Cell
Cell Theory and Its History
Microscopy and Resolution
Cell Size and the Surface-to-Volume Ratio
The Origin of Life
Check Yourself: Life and the Cell
Prokaryotes
Bacterial Structure and the Gram Stain
Bacterial Genome and Plasmids
Horizontal Gene Transfer
Pathogenicity and Antibiotic Resistance
Check Yourself: Prokaryotes
Viruses
Viral Structure
Entry and the Lytic and Lysogenic Cycles
Replication Strategies
Worked Examples: HIV, Influenza, Coronavirus, Herpes
Check Yourself: Viruses
DNA, Chromatin and the Nucleus
DNA Structure
Chromatin Packing and the Histone Code
Telomeres and Centromeres
Nuclear Envelope, Lamina and Pores
Check Yourself: DNA, Chromatin and the Nucleus
The Endomembrane System
Smooth Endoplasmic Reticulum
Rough ER and Co-Translational Import
Glycosylation, Quality Control and the UPR
The Golgi Apparatus
Check Yourself: The Endomembrane System
Vesicle Traffic
Coat Proteins: COPII, COPI and Clathrin
Targeting and Fusion: Rab and SNARE
Exocytosis
Endocytosis
Check Yourself: Vesicle Traffic
Lysosomes, Peroxisomes and Mitochondria
Lysosomes and Storage Diseases
Autophagy
Peroxisomes
Mitochondria: Structure and Endosymbiosis
Mitochondrial Genetics
Check Yourself: Lysosomes, Peroxisomes and Mitochondria
The Cytoskeleton
Actin Filaments
Microtubules, Motors and Cilia
Intermediate Filaments
Check Yourself: The Cytoskeleton
Plasma Membrane and Transport
The Fluid Mosaic Membrane
Passive Transport and Channels
Active Transport
The Na/K-ATPase and the Resting Potential
Check Yourself: Plasma Membrane and Transport
Introduction to Genetics and Genomics
History and Key Concepts of Genetics
Genome Organisation
The Human Genome Project and Gene Families
Check Yourself: Introduction to Genetics
Mendelian Inheritance
Mendel's Laws
Crosses and Probability
Sex Determination and X Inactivation
Check Yourself: Mendelian Inheritance
Extensions of Mendelian Inheritance
Dominance, Lethal Alleles and Multiple Alleles
Gene Interaction, Penetrance and Expressivity
Cytoplasmic Inheritance and Genomic Imprinting
Check Yourself: Extensions of Mendel
Human Pedigrees and Genetic Counselling
Drawing and Reading Pedigrees
Patterns of Inheritance
Twin Studies
Genetic Counselling and Prenatal Testing
Check Yourself: Human Pedigrees
Linkage and Gene Mapping
Linkage and Recombination
Genetic Maps and LOD Scores
Molecular Markers, GWAS and FISH
Check Yourself: Linkage and Mapping
Chromosomal Variation
The Karyotype
Structural Abnormalities
Numerical Abnormalities and Nondisjunction
Aneuploidy Syndromes
Uniparental Disomy, Mosaicism and Fragile X
Check Yourself: Chromosomal Disorders
Population Genetics
The Hardy-Weinberg Principle
Forces That Change Allele Frequencies
Inbreeding and Consanguinity
Check Yourself: Population Genetics
Mutation and Mutagenesis
Types of Mutation
Spontaneous and Induced Mutations
The Ames Test and DNA Repair
Check Yourself: Mutation
Epigenetics and Splicing
DNA Methylation
Histone Modifications and Non-coding RNA
Alternative Splicing and Splice Mutations
Check Yourself: Epigenetics and Splicing
Cancer Genetics
Oncogenes and Tumour Suppressor Genes
The Two-Hit Model
Genomic Instability and the Mutator Phenotype
Check Yourself: Cancer Genetics
Find the original source material on UNIVPM →